Cirrhosis Archives - AZ Clinical Trials

ALH_Facebook_Blog-Cirrhosis_22SEP2021_RD.jpg

September 29, 2021 Cirrhosisfibroscan0

Cirrhosis of the liver is a progressive disease, developing slowly over many years. If allowed to continue, the buildup of scar tissue can eventually stop liver function. Because of the gradual decline, liver cirrhosis often goes undetected and unnoticed. You can potentially catch cirrhosis from the start by knowing the signs and your risk for liver disease.

The Silent Organ

The liver is known as a silent organ because when symptoms of liver disease become apparent, it is typically in the later stages of the disease. If you’re at increased risk of liver disease, you can work with your doctor for annual screenings and lifestyle changes to protect your liver. Risk factors include:

  • Chronic alcohol abuse
  • Chronic viral hepatitis (hepatitis B, C, and D)
  • Fat accumulating in the liver (nonalcoholic fatty liver disease)
  • Being overweight
  • Insulin resistance
  • Family history

Signs of Cirrhosis

Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions. Each time your liver is injured, it tries to repair itself. This process causes the formation of scar tissue. As cirrhosis progresses, more scar tissue forms, eventually making it difficult for the liver to function (decompensated cirrhosis).

cirrhosis may cause loss of appetite

While the damage done by cirrhosis generally can’t be undone, if diagnosed early and the cause is treated, further damage can be limited and, rarely, reversed. As scar tissue accumulates, the ability of the liver to function properly is affected. The following signs and symptoms may occur:

  • Blood capillaries become visible on the skin on the upper abdomen.
  • Fatigue
  • Insomnia
  • Itchy skin
  • Loss of appetite
  • Weight loss
  • Nausea
  • Pain or tenderness in the area where the liver is located
  • Red or blotchy palms
  • Weakness

If you’re looking to get your liver health back on track, Arizona Liver Health can help. After all, liver health is in our name. We offer FREE fibroscans for adults at risk of liver disease to test for liver fat and fibrosis, which may lead to cirrhosis and liver failure. We also provide an opportunity to participate in one of our enrolling clinical trials to help advance the treatment of liver diseases for those with liver disease. To learn more, call us at 480-470-4000, or visit us online today!

Sources:

https://www.webmd.com/digestive-disorders/understanding-cirrhosis-basic-information

https://www.medicalnewstoday.com/articles/172295#treatment

https://www.mayoclinic.org/diseases-conditions/cirrhosis/symptoms-causes/syc-20351487

 

 


ALH_Facebook_Cirrhosis_18AUG2021_AW-1-1.jpg

Cirrhosis is when the permanent scarring of the liver has replaced the healthy tissue. While cirrhosis is most often associated with chronic alcohol consumption, it is brought about by many types of liver disease. Here’s how you get from liver disease to cirrhosis.

Inflammation to Fibrosis

When you have liver disease, the liver enters into a perilous cycle to heal itself. The immune system sends the signal to repair cells triggering chronic inflammation and to continue depositing collagen. In a healthy liver, the collagen stiffens around the tissue, and any extra is discarded. However, with liver disease, there is no signal to stop the inflammation discarding the excess collagen. So, the inflammation and more deposits of collagen continues. This leads to more liver stiffening and the development of fibrosis.

Fibrosis is when collagen and other proteins build up between the cells. This forms scar tissue which can block or limit blood flow within the liver, eventually starving and killing healthy liver cells. More scar tissue forms, and unlike healthy liver cells, it cannot function or repair itself.

Fibrosis to Cirrhosis

While fibrosis is reversible even into the later stages of liver disease, there is a point where the damage is too significant, and the liver can’t fix itself. No treatment can cure cirrhosis; by staying away from things that could harm your liver further, like liquor, certain drugs, and fatty food, you can help improve some of the scarrings. Treatment for individuals with cirrhosis includes managing its symptoms and treating the underlying cause to prevent liver function from worsening or liver failure. Those with cirrhosis have a high risk of developing liver cancer and eventually needing a transplant.

Our livers are versatile, continuing to work even when they’ve become seriously scarred. Most individuals with liver disease do not know it until routine blood work picks it up or symptoms become present in the later stages. Talk with your doctor about preventative measures you can take if you’re at risk of liver disease.

Regular liver checks are important for those at high risk of liver disease.

Arizona Liver Health offers FREE fibroscans for adults at risk of liver disease. A fibroscan is a quick way to determine the health of your liver and the presence of liver disease. Should your results indicate fatty liver or other liver conditions, our staff will talk with you about enrolling studies that may be an option. To learn more, call us at (480) 470-4000, or fill out a request form online today!

Sources:

https://www.webmd.com/digestive-disorders/understanding-cirrhosis-basic-information

https://liverfoundation.org/for-patients/about-the-liver/the-progression-of-liver-disease/#cirrhosis-severe-scarring


ALH_Facebook_Blog-Cirrhosis_04DEC2020_JS-2.jpg

December 15, 2020 CirrhosisClinical Research0

Cirrhosis is the replacement of healthy liver tissue with non-living scar tissue. It is a complication of liver disease from the progressive damage caused if not treated. Most people have no symptoms in the early stages, where the progression has the greatest chance of being reversed. If you are at risk for liver disease, the time to act is now.

What Causes Cirrhosis?

Cirrhosis is the result of chronic inflammation and swelling that scars the liver. It can take many years to get to this stage. Many different liver diseases can progress to cirrhosis. However, the most common ones are Hepatitis C, Alcohol-related Liver Disease (ARLD), Non-Alcoholic Fatty Liver Disease (NAFLD), and Hepatitis B.

20% of people with NASH may develop cirrhosis, liver disease research

In general, alcohol addiction and obesity are risk factors that can predispose you to liver disease and, ultimately, cirrhosis. NAFLD is the most common liver disease where fat accumulates in the liver and eventually can progress to liver failure. Insulin resistance, family history, metabolic syndrome, sedentary lifestyle, and chronic consumption of foods high in calories and fat are risk factors for NAFLD.

Cirrhosis Stages

The progression has 4 stages. The stage also determines whether the liver is compensated or decompensated. Compensated means the liver can still perform most of its essential functions despite scarring. Decompensated means the scarring now prevents the liver from functioning properly.

  1. Stage 1– Some scarring of the liver, but no complications and few symptoms.
  2. Stage 2– Blood flow through the liver becomes blocked, and pressure increases inside it. Enlarged veins that are a result of the added strain. Fatigue, itching, loss of appetite, fluid retention in legs, and bruising are more symptoms.
  3. Stage 3– The liver scarring becomes advanced, and the abdomen swells. Possible liver failure and serious complications can occur. This stage marks the transition into decompensated cirrhosis. Yellowing of the eyes and skin, brain fog, slurred speech, redness of the palms of hands, and internal bleeding are other symptoms.
  4. Stage 4– End-stage liver disease can develop, which is fatal if a transplant is not found.

Early Detection and Treatment

The liver is an amazing organ that can regenerate itself. Even with some scarring, the liver can heal itself well into the later stages when caught and treated. Cirrhosis has no cure. Though, by addressing any underlying conditions, making healthier lifestyle changes, and medications to control symptoms, patients can manage the progression. If you’re at risk, talk with your doctor.

Did you know fatty liver can lead to cirrhosis, liver disease research

Arizona Liver Health conducts free fibroscans that can detect diseases of the liver such as NAFLD and NASH. Once results are ready, our medical staff will help you determine if additional steps are needed. If your results indicate abnormal liver function, our team will discuss enrolling studies for the liver that may be an option. Schedule your FREE fibroscan today! Request an appointment here.

References:

https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/cirrhosis/#information-for-the-newly-diagnosed

https://www.medicinenet.com/cirrhosis/article.htm

https://www.webmd.com/digestive-disorders/understanding-cirrhosis-treatment#2



Social networks


Facebook

www.facebook.com/azclinicaltrials


Twitter

@azclintrials


Instagram

@azclinicaltrials



Locations


Mesa Office

2152 S Vineyard Ave Ste 123
Mesa, AZ 85210
480-360-4000


Tucson Office

1601 N Swan Rd
Tucson, AZ 85712
520-445-4000


Call us to see if you or your patient qualify for a clinical trial.